A new study published in the American Journal of Perinatology aimed to evaluate the clinical aspects outcomes and management strategies of trisomies 13 and 18. In this retrospective cohort study 69 cases with such trisomies were reviewed between January 1996 and January 2016. The findings showed that in almost all pregnancies with follow up at least one indication present for invasive testing. However invasive testing was not performed in 18.5 of such cases. All parents opted for termination in cases with prenatal diagnosis. While none of the live borns had prenatal diagnoses thus neonatal resuscitation and intensive care unit admission were not withheld in such infants. Major intervention was done in only one patient with full trisomy 13. Median survival for infants with full trisomies 13 and 18 was 36 and 60 days respectively almost half the patients died within 1 month. The results of this review suggested that the extent to which the major interventions should be withheld is an issue of debate in managing such infants.