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A structured graduated protocol with heat denatured eggs in the treatment of egg allergy.

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eMediNexus    22 August 2019

A new study published in Pediatric Allergy and Immunology evaluated the efficacy and safety of a structured gradual exposure protocol (SGEP) with extensively heated and baked egg (EHBE) in promoting tolerance to eggs in egg allergy (EA) children. This was a control study, wherein EA children below 2 years of age were treated with SGEP including EHBE. These children were compared to children with EA under strict avoidance. Overall, 39 EA children were treated with SGEP, with a median age-at-intervention of 16 months who were followed up to a median age of 39 months. The findings showed that the median estimated age at EA resolution in the SGEP group was 24 months compared to 78 months in the control group. It was noted that at the last follow up, 82% of the children who received intervention were tolerant to lightly cooked eggs versus 54% of controls. Therefore, it was concluded that a structured protocol with EHBE could promote faster resolution of EA.

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