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Sensitization to grass allergens -Phl p1, Phl p5 and Phl p7 Phl p12 in adult and children patients.

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eMediNexus    05 September 2019

A new study published in Allergologia et Immunopathologia aimed to derive knowledge of sensitizations to molecular allergens in children and adults, which could contribute to better diagnosis and treatment of allergies.The present study utilized Immuno CAP singleplex technology for molecular allergens. In 45 patients with positive grass sensitization tests, g205 (Phl p1); g215 (Phl p5b); g210 (Phl p7); and g212 (Phl p12) allergens were determined. The results revealed that a majority of patients are sensitized to Phl p1 (91%), while Phl p1+/Phl p5-/Phl p7-/Phl p12- was the most dominant profile (40%). In the adult group, the IgE averages for Phl p1 were approximately 10.46; they were 8.43 for Phl p5; 0.69 for Phl p7; and 0.06 for Phl p12. In the child group, these values were higher¬¬¬¬– 22.49, 20.23, 3.89, and 0.35, respectively. Meanwhile, for allergens Phl p1, Phl p5, and Phl p7, such differences between populations were not statistically significant, but for Phl p12, a statistically significant difference was observedamongchildren and adults.Therefore, it was concluded that IgE antibodies Phl p1 is the most important allergic marker, and that, sensitivities caused by Phl p12 render higher IgE values in children.

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