A new study published in Respiratory Medicine aimed to describe the phenotypic clusters of asthma in a multi-ethnic Southeast Asian cohort and to make direct comparisons with other established phenotypes, in order to investigate how ethnicity affects phenotypic expression. This study recruited 630 adult asthma patients from two healthcare institutions in Singapore, who were randomly assigned to a test and a validation cohort with the ratio of 2:1. Here, phenotypic clusters between the test and validation cohorts were compared. The results identified three clusters in both, the test and validation cohorts—with corresponding clusters of each cohort sharing similar characteristics. Ethnic representation and asthma control were significantly different between clusters. Cluster one comprised Chinese females with late-onset asthma and the best asthma control; cluster two comprised non-Chinese females with obesity and the worst asthma control; and cluster three was multi-ethnic with the greatest proportion of atopic patients. Thus, three phenotypic clusters were recognized in a multi-ethnic Southeast Asian population with distinct differences in ethnicity, which was speculated to be attributable to inherent differences in baseline characteristics among ethnic groups.