A new study published in The Journal of Allergy and Clinical Immunology investigated the relationship between chronic rhinosinusitis (CRS) and its comorbidities.The present study entailed an investigation of the potential relationship between CRS and comorbidities—asthma, acute myocardial infarction (AMI), stroke, anxiety disorder and depression, using a representative sample.Overall, 1,025,340 patients from the Korean National Health Insurance Service database from 2002-2013, including 14,762 patients with CRS and 29,524 without CRS were included. Cox-proportional hazards model was used to analyze the hazard ratio (HR) of CRS for asthma, AMI, stroke, anxiety disorder and depression.The results showed that the incidence of asthma, AMI, and stroke were 71.1, 3.1 and 7.7 per 1000 person-years in CRS patients, respectively. The adjusted HRs of asthma, AMI and stroke were 2.06, 1.29 and 1.16, respectively, in CRS versus non-CRS patients. The incidence of anxiety disorder and depression in CRS patients was 42.1 and 24.2 per 1000 person-years, respectively. Moreover, the adjusted HRs of anxiety disorder and depression were significantly greater in patients with versus without CRS. From the results, it was concluded that CRS is associated with an increased incidence of asthma, AMI, stroke, anxiety disorder and depression. It was suggested that clinicians should monitor CRS patients carefully, and optimize management as a means to potentially decrease these other associated comorbid conditions.