The purpose of a new study published in The Journal of Allergy and Clinical Immunology was to determine whether unique features of cough frequency (CoFr) exist in asthmatic and non-asthmatic patients, and to evaluate relationships between CoFr and pathophysiological parameters of asthma.This study enrolled 73 asthmatic and 63 non-asthmatic patients suffering from persistent cough. At baseline, the Leicester Cough Questionnaire (LCQ health status), cough visual analogue scale (VAS), Leicester Cough Monitor (LCM), fractional exhaled nitric oxide (FeNO) measurements and spirometry were performed. In asthmatic patients, bronchial hyperresponsiveness (BHR) test was conducted if applicable. In 28 asthmatic and 17 non-asthmatic patients, LCQ, VAS and LCM were examined before and after treatment.The findings revealed that CoFr during night-time (asleep) was significantly higher in asthmatic patients than in non-asthmatic patients. While the 24-hour CoFr significantly decreased after appropriate treatment and was correlated with changes in VAS and LCQ in all patients. The improvement in cough in asthmatic patients was greater during night-time than during daytime (awake). Meanwhile, CoFr in asthmatic patients was significantly correlated with BHR, but not with FeNO.The results suggested that in asthmatic patients, nocturnal CoFr can be associated with BHR. It was noted that CoFr was significantly higher before treatment, but improved in asthmatic patients, after treatment compared to non-asthmatic patients. Thus, it was inferred that monitoring nocturnal CoFr may provide unique and valuable information on making an early prediction of therapeutic effects in asthma.