A new study published in Pediatric Allergy and Immunology aimed to determine the association between respiratory syncytial virus (RSV) infection and recurrent wheezing (RW) and asthma among full-term infants. This study entailed an estimation of the risk of RW/asthma during the first 5 years of life, in full-term infants hospitalized with RSV before attaining the age of 1 year, using 2010-16 data from three claims databases in USA – Truven Market Scan Commercial Claims and Encounters Database (CCAE); Truven Health Market Scan Multi-State Medicaid (MDCD); and Optum Clinformatics Extended Data Mart-Socio-Economic Status (SES). Full-term infants with and without RSV infection and ≥2 years of continuous health plan enrollment from birth were included. Incidence of RW/asthma, cumulative incidence, adjusted incidence rate ratios (aIRR) and adjusted odds ratios (aOR) were calculated. The results revealed that during the study period, 38494 (CCAE), 62846 (MDCD) and 23,099 (SES) matched infant-pairs were included in each cohort. In the CCAE database, RW/asthma incidence/1000 patient-years; cumulative incidence; and aOR were higher in the RSV relative to non-RSV cohort. Results in the SES insured population were comparable. Meanwhile, cumulative incidence and aIRR were higher in the Medicaid population (MDCD).The findings indicatedthat full-term infants with severe RSV infection during the first year of life, spanning several respiratory seasons and a geographically diverse population, are at significant risk of RW/asthma during childhood.