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An injection of the investigational osteoarthritis drug sprifermin into the knee joint every 6 or 12 months resulted in statistically significant improvement in cartilage thickness after 2 years compared with placebo, suggests new research.
However, the authors say, both the clinical importance and the question of whether the 2-year improvement will last 5 years are uncertain. The results from the phase 2 FORWARD trial (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses), a dose-finding, 10-site, randomized clinical trial involving patients with symptomatic knee osteoarthritis, were published online October 8 in JAMA.