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Dr KK Aggarwal 17 October 2019
A combination of lumacaftor and ivacaftor has been found to improve lung function in cystic fibrosis patients and also reduced the need for intravenous (IV) antibiotics in a new study published online Oct. 11, 2019 in the American Journal of Respiratory and Critical Care Medicine.
The study conducted at 47 cystic fibrosis centers in France involved 845 patients, both adolescents and adults. Patients who took lumacaftor-ivacaftor continuously for 12 months experienced:
The combination therapy was also associated with a reduction in frequent (≥ 2) exacerbations per year.
About 18% of participants in the study dropped out. Nearly half the patients who discontinued treatment did so because of adverse respiratory events and more than a quarter discontinued the treatment due to adverse non-respiratory events, most often digestive problems.
Lumacaftor-ivacaftor combination has been approved by the US FDA and EMA in 2015 for treatment of cystic fibrosis patients who have inherited the same defective CFTR gene (Phe508del mutation)….(Excerpts from American Thoracic Society)
Dr KK Aggarwal
Padma Shri Awardee
President Confederation of Medical Associations in Asia and Oceania (CMAAO)
Group Editor-in-Chief IJCP Publications
President Heart Care Foundation of India
Past National President IMA
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