IL-17C is an epithelial derived cytokine, whose impact on skin inflammation is unclear.The purpose of a new study published in Journal of the European Academy of Dermatology and Venereology was to characterize the role of interleukin (IL)-17C in inflammatory skin disorders (ISD).Here, IL-17C gene and protein expressions were assessed by immunohistochemistry and transcriptome analysis.Primary human keratinocytes were stimulated and expression of cytokines chemokines was determined. Neutrophil migration towards supernatant of stimulated keratinocytes was assessed.The results showed that the expressions of IL-17C mRNA and protein were elevated in various ISD. It was observed that IL-17C potentiated the expression of innate cytokines, antimicrobial peptides (IL-36G, S100A7, HBD2) and chemokines (CXCL8, CXCL10, CCL5, VEGF) and the autocrine induction of IL-17C in keratinocytes. While cell-free supernatant of keratinocytes stimulated with IL-17C was strongly chemotactic for neutrophils, demonstrating a critical role for IL-17C in the immune cell recruitment. Furthermore, IL-17C depletion led to a significant downregulation of inflammatory mediators in human skin biopsies of psoriasis and atopic eczema, ex vivo.Hence, it was concluded that IL-17C amplifies epithelial inflammation in T-helper (Th)2 and Th17 dominated skin inflammation and represents a promising target for the treatment of ISD.