Dysbiosis of skin microbiota is associated with several inflammatory skin conditions, including atopic dermatitis, acne and hidradenitis suppurativa. A new study published in PLoS One examined the feasibility of transferring unenriched skin microbiota communities between two anatomical sites of the same host, with objective of exploring targeted bacteriotherapy to treat various dermatologic conditions. In this prospective pilot study, four healthy volunteers were selected, who belonged to the age-range of 24-36years—two were females. Participants underwent collection and transfer of skin microbiota from the forearm to the back unidirectionally. The baseline and mixed("transplant") communities were compared at T = 0 and T = 24 hours, using culture methods and 16S rRNA V1-V3 deep sequencing. The ability to detect movement from one site to the other relied on the inherent diversity of the microenvironment of the antecubital fossa relative to the less diverse back. Evidence of transfer of a partial DNA signature was detected on comparing bacterial species present in the arm and mixed ("transplant") communities that were absent from the baseline back. However, these methods couldn’t assure the viability of transferred organisms. It was concludedthat unenriched transfer of whole cutaneous microbiota is challenging, but this simple technique that intended to move viable skin organisms from one site to another must be further investigated.