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Fractional flow reserve (FFR) makes a different impact on treatment decisions if diabetes is involved, registry data showed.
The proportion for which FFR would reclassify the treatment strategy was similar between those with and without diabetes (41.2% vs 37.5%, P=0.13) in two merged registries. Compared with controls; however, diabetic patients were more likely to be reclassified from medical therapy to revascularization than the other way around. Among diabetic patients, FFR-based deferral of stenting or surgery resulted in an 8.4% 1-year rate of major adverse cardiovascular events (MACE: all-cause death, MI, or unplanned revascularization) compared to 13.1% for those who proceeded with revascularization (P=0.04). The findings were published in JAMA Cardiology.