Deka and colleagues conducted a study to assess the effect of methanolic extract of Cissus quadrangularis Linn (CQ) on healing of experimentally fractured radius-ulna.

CQ treated experimental models had faster initiation of healing process in comparison with control models, as noted on radiological and histopathological examinations. CQ-treated models exhibited bony dissolution and periosteal reaction at the fractured sites on the 11th day of fracture, as noted by radiograph. The control group had comparatively less bony dissolution and periosteal reaction was absent.

CQ-treated models showed a greater reduction in serum calcium level than the control group. Healing was almost complete on 21st day of fracture in the treated models while it remained incomplete in the control models. There was evidence of almost complete bridging of the fractured ends with extensive bony deposition and periosteal reaction in CQ-treated group.

The findings thus revealed accelerated healing with increased osteoblastic activity on 11th day of fracture and presence of bony trabeculae on the 21st day of fracture in the treated group.

Reference

1. Deka DK, Lahon LC, Saikia J, Mukit A. Effect of Cissus quadrangularis in accelerating healing process of experimentally fractured radius-ulna of dog: a preliminary study. Indian Journal of Pharmacology 1994; 26: 44 – 45.