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#Business And Medicine #Pathology and Lab Medicine #Public Health
London: Supercharging the mutation rate in cancer cells could create a powerful vaccine that can boost the effectiveness of immunotherapy, suggests a new study published in the journal Nature Communications.
Scientists forced cancer cells in the lab to evolve much more rapidly than usual with the help of a molecule called APOBEC3B, often used by tumors to drive rapid genetic change and drug resistance. These highly mutated cancer cells could be used to create a vaccine for each individual cancer type, which enhanced the effects of immunotherapy and cured mice with some otherwise treatment-resistant tumors, revealed the study… (ET Healthworld – IANS, February 9, 2020)