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eMediNexus 14 February 2020
The purpose of a new study published in American Journal of Human Biology was to describe the validation of a commercial ELISA assay to measure osteocalcin—a biomarker of bone formation—from dried blood spots (DBS).
This study entailed the validation of the Osteocalcin Human Simple Step ELISA kit from Abcam (ab1951214) using 158 matched plasma and DBS samples. Limit of detection, analyte stability and specific forms of osteocalcin measured by the kit were also investigated.
The results revealed that:
The findings suggested that osteocalcin can be measured from DBS. Combined with a previously validated DBS assay for TRACP-5b—a bone resorption biomarker—these assays have the potential to shed light on and further clarify many factors contributing to bone strength.
Source: American Journal of Human Biology. 2020 Feb 4:e23394. doi: 10.1002/ajhb.23394.
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