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Anti-nociceptive effect of Cissus quadrangularis

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eMediNexus    21 February 2020

Cissus quadrangularis has long been in use for the treatment of fracture of bones. Evidence suggests that C. quadrangularis extract promotes the healing of fractured bones.

A study was conducted to assess the centrally and peripherally acting analgesic property of water:chloroform (80:20) extract of C. quadrangularis in experimental models. Control models received a vehicle; Pentazocine was used as positive control; Test group received extracts of C. quadrangularis (250 and 350 mg/kg). Each group had 5 study subjects.

C. quadrangularis extract administered at a dose of 350 and 250 mg/kg demonstrated significant analgesic activity in hot plate method, as evidenced by increase in latency time. It was maximum for the 350 mg/kg dose. Percentage pain inhibition was higher in the 350 mg/kg group (Fig. 1). In the formalin test, C. quadrangularis significantly decreased the licking time. The extract inhibited both the first phase (neurogenic pain) as well as the second phase (inflammatory pain). The extract also inhibited the writhing reaction induced by acetic acid. The 350 mg/kg dose led to a significant reduction in the writhing reaction (Fig. 2).

The findings thus revealed that C. quadrangularis extract has potent analgesic activity which is dose-dependent.

Fig. 1. Percentage pain inhibition at 90 minutes in hot plate test

Fig. 2. Percentage inhibition of acetic acid-induced writhing reaction

Reference

  1. Mate GS, Naikwade NS, Magdum CS, et al.Evaluation of anti-nociceptive activity of Cissus quadrangularis on albino mice.International Journal of Green Pharmacy 2008;2(2):118-21.

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