A new study published in Wiadomosci Lekarskie evaluated the influence of local oxygen deficiency on features of formation of keloid scars of the head and neck.

This study used 17 incisional biopsy specimens of keloid scars which were derived from the highest age categories of patients – 19-63 years.

The results showed coloring, according to the Mallorys technique, and sections of fibrinoid swelling of collagen fibers near central homogeneous hyaline masses. The lateral areas of the dermis—that were adjacent to the keloid scar tissue at coloring by the Hart method—were characterized by separation of the hyalinosis zone from the undamaged dermis by coarse bundles of elastic fibers, colored in dark purple. The undifferentiated dysplasia of the connective tissue was said to have caused the replacement and obstruction of single vascular components, which in turn, complicated the local oxygen deficiency of keloid-altered tissues.

It was concluded that plasmaragia and the accumulation of protein deposits in the perivascular space determine the inhibition of local hemodynamics, which explains the decrease in oxygen transport to tissues. Decreased oxygenation and increased permeability of the vascular wall causes local hemocirculatory hypoxia.

Source: Wiadomosci Lekarskie. 2020;73(3):565-568.