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Preparation and Evaluation of Sunscreen Nanoemulsions with Synergistic Efficacy on SPF

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Soybean oil contains vitamin E and acts as a natural sunscreen which can absorb Ultra Violet (UV) B light and has antioxidant properties to reduce the photooxidative damage that results from UV-induced Reactive Oxygen Species production.

A recent study published in Open Access Macedonian Journal of Medical Sciences evaluated the in vitro efficacy of sunscreen nanoemulsion containing Soybean oil, Avobenzone and Octyl methoxycinnamate.

Here, sunscreen nanoemulsions were prepared by the high energy emulsification method. The formulation comprised a combination of 3% Avobenzone, 7.5% Octyl methoxycinnamate, with different ratio of Soybean oil and Liquid Paraffin. The nanoemulsion was evaluated for droplet sizes by using particle size analyzer, physical stability in room temperature (25 ± 2°C during experiment for 12 weeks of storage); physical stability (cycling test); phase separation (by centrifugation at 3750 rpm for 5 hours); pH; viscosity; and Sun Protection Factor (SPF) value by UV spectrophotometric. The SPF value of sunscreen nanoemulsion was compared to sunscreen nanoemulsion without Soybean Oil and sunscreen emulsion.

It was found that the sunscreen nanoemulsion formulation—combination of 3% Avobenzone, 7.5% Octyl methoxycinnamate with a ratio of 2.73% Soybean Oil and 0.27% Paraffin Oil—resulted in the smallest average droplet size of 68.47 nm. Whereas, sunscreen nanoemulsion without Soybean Oil had an average droplet size of 384.07 nm. The globules size was increased during the experiment for 12 weeks of storage at room temperature, but there was no phase separation after centrifugation. The formulation of sunscreen emulsion, phase separation was formed after centrifugation; the nanoemulsion had a pH value of 7.23 ± 0.06 and viscosity of 133.33 ± 7.22 cP. The sunscreen nanoemulsion—combination of 3% Avobenzone, 7.5% Octyl methoxycinnamate 2.73%, Soybean Oil, 2.73% and 0.27% Liquid Paraffin—had an SPF value (21.57 ± 1.21) higher than sunscreen nanoemulsion without Soybean Oil (16.52 ± 0.98) and sunscreen emulsion (15.10 ± 0.22). Furthermore, Transmission Electron Microscope (TEM) analysis of globules morphology showed that the sunscreen nanoemulsion formed a spherical globule.

Therefore, the sunscreen nanoemulsion – with 3% Avobenzone, 7.5% Octyl Methoxycinnamate, 2.73% Soybean Oil and 0.27% Liquid Paraffin, showed synergistic sunscreen efficacy on SPF. It was stated that this sunscreen nanoemulsion is more stable than sunscreen emulsion formulation during the experiment for 12 weeks at room temperature.

Source: Open Access Macedonian Journal of Medical Sciences. 2019 Aug 30;7(17):2751-2756. doi: 10.3889/oamjms.2019.745.

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