The development of atopic dermatitis (AD) is generally associated with the occurrence of pathogenic microflora in the biotope of the skin against the background of acute immunological disorders of the microorganism. Staphylococcus aureus plays the leading role and is seeded in 80-95% of patients diagnosed with AD. The clinical importance of the pathogen is determined by its capability to actively persist in the biotope, which is assisted by a wide range of pathogenicity factors of this microorganism. The main objective of the research is to study the activity levels of pathogenicity factors and the tenacity of staphylococci clinical autostrains that are isolated from different topodems of the skin of AD patients. The study object was 101 laboratory strains of the skins staphylococci of 50 AD patients and 39 control strains isolated from 20 healthy individuals. Isolation of microorganisms along with their bacteriological studies of their pathogenic characteristics were carried out by the methods of standard bacteriology. It was discovered that the qualitative and quantitative characteristics of the antilysocyme activity (ALA), the anti-interferon activity (AIA) and the adhesive properties of the strains that were isolated from the affected skin areas were considerably higher than that of the cultures isolated from the intact areas of the skin. Thus, the data achieved specify the ability of these pathogens to unfavorably affect the development of the pathological process in the skin.

Source: Kutasevych Y, Dzhoraeva S, Shcherbakova Y, Bondarenko G, Sobol N. The study of skin autofloras pathogenic properties in patients diagnosed with atopic dermatitis. Georgian Med News. 2019 Jul-Aug ;( 292-293):113-117.