A recent article published in Current Gastroenterology Reports reviewed the scientific rationale and modifications of oral rehydration solution (ORS) and barriers to universal application.

The findings of this report suggested that solutions with osmolality and electrolyte composition different from original ORS for routine and unique pathophysiology – such as in malnutrition, have encountered varying success. In addition, following the conceptual rationale of sodium-glucose co-transportation to facilitate water absorption. Other cotransporters and formulations have been explored with the aim to improve ORS efficacy and acceptance.

In inference, it was stated that ORS remains the anchor of acute watery diarrhea and dehydration management worldwide. Despite development of different formulations, the current standard solution is the mainstay of treatment in most scenarios. Further efforts to improve oral hydration solution and to increase acceptance and usage are ongoing.

Source: Current Gastroenterology Reports. 2019 Dec 7;21(12):67. doi: 10.1007/s11894-019-0734-1.