A recent article published in Mini Reviews in Medicinal Chemistry discussed that cutaneouspigmentation plays a critical role in determining the color of skin, along with photo protection of skin from dreadful effects of ultraviolet radiations. On the other hand, abnormal accumulation of melanin is responsible for hyperpigmentary disorders such as melasma, senile lentigines and freckles.

The authors stated that owing to the visible nature of dermatologic diseases, they have a considerable psychosomatic effect on the affected patients. Mechanism of pigmentation is characterized by the intact process of synthesis of specialized black pigment within melanosomes. Melanin is synthesized by a cascade of enzymatic and chemical reactions. For this reason, melanin production is mainly controlled by the expression and activation of tyrosinase.

This article reported that the tyrosinase inhibitors are molecules that interrelate in some waywith the enzyme—to prevent it from working in its normal manner. Over a few decades in the past, scientists have engaged in the development of natural tyrosinase inhibitors for the imperative role played by tyrosinase in the process of melanogenesis, and fungi or fruit enzymatic browning.

In inference, it was stated that tyrosinase inhibitors from natural sources can be used asessential constituent of cosmetics products and depigmenting agents for the treatment of hyperpigmentory disorders.

Source: Mini Reviews in Medicinal Chemistry. 2019;19(10):796-808.doi:10.2174/1389557519666190116101039.