Coronavirus Live Count Map India
remove_red_eye 1849 Views
Coronavirus Live Count Map World
#Allergy and Immunology #Multispeciality
Anti-viral immunity is vital to recover from COVID-19 infection. Micronutrient deficiency suppresses immune functions by affecting the T-cell-mediated immune response and adaptive antibody response, and alters the balanced host response. Supplementation with certain vitamins/trace elements enhances immunity in viral infections. Zinc is essential for normal function and development of cells regulating nonspecific immunity, including natural killer cells and neutrophils. It plays a key role in growth, development, and maintenance of immune function. Zinc status is a critical factor that affects immunity against viral infections
The Zinc factor in anti-viral immunity
- Reduces production of type I IFNs and interferon stimulated genes (ISGs) CD80 and CD86 in response to TLR7 activation
- Inhibits IRF3-, and IRF7-dependent production of IFNB
- Stimulates expression of the deubiquitinating enzyme A20 to inhibit pathogen response
- Reduces IFN secretion by destabilizing sortilin mRNA transcripts
- Inhibits IκB kinase (IKK) members IKKa and IKKβ
- Increases IFN a production by leukocytes
- Inhibits IFN-λ3 signaling
- Inhibits protein tyrosine phosphatase enzymatic activity
Source: Diabetes Metab Syndr. 2020 Apr 16. Adv Nutr 2019;10:696–710. Int J Mol Med 2020 Apr 14.
To comment on this article,
create a free account.
Already registered?
.jpg)
