A recent study published in The Journal of Dermatological Treatment evaluated the effect of conventional and double doses of fexofenadine HCl on chronic idiopathic urticaria (CIU) and on histamine-induced skin responses by iontophoresis using visual and laser Doppler imaging scales in healthy donors. Here, the effect of conventional and double doses of fexofenadine HCl on CIU and on histamine-induced skin responses were evaluated by iontophoresis using visual and laser Doppler imaging scales in healthy donors. It was observed that cutaneous manifestations in CIU and histamine-induced flare and itch in healthy donors were attenuated more extensively by a double dose of fexofenadine HCl compared to a conventional dose. The findings of this study sustained the management strategy that increasing the dose of non-sedative antihistamines is the second-line treatment choice for refractory CIU.