A new study published in The Journal of Dermatological Treatment investigated the effectiveness and safety of emollient preparations in comparison with the emollient ointment containing glycerophosphoinositol salt of choline in patients with atopic dermatitis (AD).

This was a real-life study, wherein 300 patients with moderate AD were age-stratified and divided into two groups – patients applying GPI emollient, and a comparator. The effectiveness of AD treatment was evaluated using the Eczema Area and Severity Index (EASI), Three Item Severity (TIS), Visual Analogue Scale (VAS) and Four-Item Itch Questionnaire.

The findings revealed that the GPI emollient was superior in reducing AD symptoms in children – VAS (-2.58 ± 0.25), TIS (-2.22 ± 0.22), EASI (-15.27 ± 1.77) and in adults – VAS (-2.42 ± 0.19), TIS (-2.22 ± 0.17), EASI (-13.22 ± 1.53), as compared to the other emollients in children and adults. Equivalent results were observed in the Four Item Itch Questionnaire.

Hence, both emollients showed good safety and tolerance profile and reduced AD symptoms. The results suggested that GPI emollient seems to be more effective in reducing AD symptoms as compared to the other commercially available emollients.

Source: The Journal of Dermatological Treatment. 2020 Aug 4;1-12. doi: 10.1080/09546634.2020.1800567.