Zinc, an essential micronutrient, has a potential role in the regulation of innate and adaptive immune responses. Malnutrition is a major cause of zinc deficiency. This multipurpose metal is vital for the growth and function of all cells. The immune system is particularly affected by alteration of zinc homeostasis.

Zinc is involved in the modulation of the proinflammatory response via targeting nuclear factor kappa B (NF-κB), a transcription factor which is the key regulator of proinflammatory responses. It is also involved in controlling oxidative stress and regulating inflammatory cytokines. This micronutrient play a complex function during an immune response and its homeostasis is pivotal for sustaining proper immune function.

Achieving optimal immune response to different stimuli and avoiding damage of tissues and organs is a delicate balance that depends on the regulation of zinc in extracellular and intracellular compartments. Resolving zinc deficiency and the adverse manifestations associated with it can be achieved through adequate diet and supplementation.

Source: Nutrients. 2017 Jun; 9(6): 624.