In a study, it was suggested that the formulations containing antioxidants led to a significant reduction of skin hyperpigmentation following the period of application. Certain In vitro studies have demonstrated that certain antioxidants can reduce melanogenesis. To establish the clinical efficacy of antioxidants in reducing skin hyperpigmentation, a study was conducted in thirty-two healthy females aged 39-55 years. The purpose of the study was to gauge the clinical efficacy of dermo-cosmetic formulations based on antioxidants using Reflectance confocal microscopy (RCM). The findings of the study indicated that a significant reduction of the number of hyperreflective pixels and basal layer brightness following 42 days of application of formulations containing the antioxidants compared with vehicle and baseline values. The results were suggestive of an improvement of the skin-pigmentation pattern.