A recent study demonstrated that the subcutaneous hyaluronic acid fragments mixed with amino acid infiltration had a consider able influence on the dermis and clinical aspects of the face. Hyaluronic acid is one of the techniques sued for improving the quantity of water and extracellular matrix molecule. In the study, the effect of low-molecular-weight hyaluronic acid fragments mixed with amino acid on the facial rejuvenation of skin treated with intradermal microinjections was assessed. The study included 20 women with mean age 45 years and was treated with the HAAM products by mesotherapy technique. The study results showed that the administration of the dermal filler comprising fragments of hyaluronic acid between 20 and 38 monomers and amino acid through dermis injection technique leads to an amplified fibroblast activity with the creation of type III reticular collagen and increased thickness of vessels and epidermis.