Cough Update: Effectiveness and safety for the combination of levosalbutamol, ambroxol and guaifenesin for the productive cough treatment |
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Cough Update: Effectiveness and safety for the combination of levosalbutamol, ambroxol and guaifenesin for the productive cough treatment

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One of the most common symptoms that many doctors and general physicians treating paediatric population is cough. Cough can be of two types: productive or unproductive. With the combination of bronchodilator, mucolytics and expectorant, productive cough can be managed and treated.

Phase IV clinical trial was conducted and the main objective of the trial was to evaluate the efficacy and safety for the combination of Levosalbutamol (bronchodilator), Ambroxol hydrochloride (mucolytic agent) and Guaifenesin (expectorant) for the treatment of productive cough that is associated with bronchospasm in bronchitis and bronchial asthma and also in all conditions associated with wheezing, tenacious mucus and chest congestion.

The clinical trial was conducted with twenty-three paediatric speciality doctors on 325 patients. Out of them, 149 patients were from 2 to 12 years of age group and 176 patients were below 1 year of age. Efficacy evaluation was conducted by analysing the cough severity score (CSS) at each visit. Safety evaluation was conducted by analysing the adverse events that were experienced by the patients or observed by the investigators in all the visits.

At baseline, CSS was 6.624 and it reduced to 3.744 on the 3rd day and 1.049 on the 5th day. One-point decrease in Likert type symptom scale from moderate to mild was in only just 5 days. 12.923 % of patients experienced non-serious adverse events.

The study concluded that the combination of Levosalbutamol, Ambroxol Hydrochloride and Guaifenesin was very safe and efficient for the productive cough treatment.

Source: Kiran, D. M. D., Pawaskar, L. J., & Sheikh, S. N. (2019). Efficacy and Safety for the Combination of Levosalbutamol, Ambroxol and Guaifenesin for the Symptomatic Treatment of Productive Cough: Phase IV Clinical Trial. International Journal of Innovative Research in Medical Science, 4(01), 11 to 15. https://doi.org/10.23958/ijirms/vol04-i01/537

 

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