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Association between the age-related decline in renal function and lumbar spine bone mineral density.

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eMediNexus    26 December 2017

A new study published in Menopause investigated the association between age-related decline in renal function and lumbar spine bone mineral density (LBMD) in healthy Chinese postmenopausal women. This was a community-based cross-sectional study of 390 healthy postmenopausal women (mean age 62.97 ± 8.79 years) from Shenyang, China. The findings showed that estimated glomerular filtration rate (eGFR)-ASIA and eGFR-Scys were positively correlated with LBMD. After adjustments for numerous potential confounders, the odds ratio for participants with LBMD decline in eGFR-ASIA quartile 3 group and 4 group were 2.45 and 3.89, respectively, with P = 0.003 for the trend in eGFR-ASIA compared with the lowest quartile 1 group of eGFR-ASIA. Whereas, the odds ratio of eGFR-Scys for the quartile of 3 and 4 groups were 2.47 and 2.63, respectively, with P = 0.016 for the trend in eGFR-Scys compared with the lowest quartile 1 group of eGFR-Scys. From the findings, it was inferred that the renal function decline was independently associated with decreased LBMD, and it was possible that the age-related decline in kidney function was an independent risk factor for decreased LBMD in healthy Chinese postmenopausal women.

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