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Tyrosinase inhibitors have gained interest in the cosmetics industry to prevent hyperpigmentation and skin-related disorders by inhibiting melanin production.
A new study published in Fitoterapia aimed to discover Aloe species that exhibit anti-tyrosinase efficacy.
In this study, exudates of 39 African Aloe species were screened to identify species and compounds with anti-tyrosinase activity.
The findings showed that among the ones tested, 29 Aloe species exhibited tyrosinase inhibition activity with one to three active bands. Quantitative screening expressed as IC50 values. Three species were further analyzed and subsequently, aloesin and aloeresin A was isolated from A. ferox; plicataloside from A. plicatilis; and A. chabaudii. Aloeresin A was determined to be a substrate of mushroom tyrosinase.
Dose-response assays showed that aloesin (IC50 = 31.5 μM) and plicataloside (IC50 = 84.1 μM) exhibited moderate to weak activity. Meanwhile, molecular docking scores for plicataloside were considerably lower than for aloesin—confirming its lower IC50.
It was concluded that several Aloe species may have potential for the management of hyperpigmentation or as a skin lightening agent.
Source: Fitoterapia. 2021 Jan 9;104828. doi: 10.1016/j.fitote.2021.104828.