A new article published in Pharmaceutics reported that semisolid dosage forms are recommended for dermal care of babies and children. Among ingredients of these preparations, there are many substances, for example – occlusive agents and preservatives, that no longer meet certain requirements of the modern age. Hence, it is necessary to replace them with other substances.

The present study aimed to devise a science-based formulation with new components that keep or improve its moisturizing properties, rheological parameters and microbiological stability.

This experiment entailed the replacement of occlusive oils – like white petrolatum and liquid paraffin and the preservative parabens – traditional ingredients in oil in water creams, with white beeswax, sunflower oil and phenoxyethanol, respectively. Cocoa butter, urea and glycerol were added to improve long-lasting hydration and support the barrier function of the reformulated creams. The rheological properties of the formulations were determined. The effects of the preparations on skin hydration and on the barrier function of the skin were tested. Furthermore, microbiological stability was investigated.

The result of the reformulation was an o/w cream that provided a good longer-lasting hydration effect. While it supported the barrier function of the baby skin without occlusion and had adequate consistency, easy spreading, a pleasant skin feeling, proper pH and good microbiological stability.

Source: Pharmaceutics. 2020 Aug 4;12(8):729. doi: 10.3390/pharmaceutics12080729.