Patients with type 2 diabetes with the highest variability in A1c levels over a period of 2 years were found to have significantly more first cardiovascular disease (CVD) events compared to similar patients with less A1c variability, reported a retrospective analysis of over 29,000 US patients.

Patients in the quartile with the greatest level of A1c variability were shown to have a 59% higher rate of CVD events, in comparison with patients in the quartile with the lowest level of A1c variability. Every 1 unit rise in A1c standard deviation was tied to a significant 18% increase in CVD events after adjusting for confounders. The results were published in Diabetes Obesity and Metabolism… (Medscape)