Alloveda Liver Update: Importance of estrogen in chronic liver diseases |
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Alloveda Liver Update: Importance of estrogen in chronic liver diseases

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Sex hormones such as estrogens have an important role in regulating sexual function and various pathophysiological processes. They exhibit a non-reproductive role as the modulators of the immune system, growth, neuronal function, and metabolism. Estrogen receptors are expressed in the liver and their impaired expression and function results in obesity and liver associated metabolic dysfunctions. The current study is aimed to understand the disparity role of estrogens on several forms of liver diseases. The review included a comprehensive search in PubMed and EMBASE using the keywords “estrogens and liver diseases”, “estradiol and liver diseases”, “hormones and liver diseases”, “endocrine function in liver diseases”, and “female hormones in liver diseases”. 

The outcomes establish the evidence that estrogen has an imperative role in several forms of chronic liver diseases. They are vital in maintaining homeostasis and reduce the susceptibility of the liver to several forms of chronic liver diseases in healthy premenopausal individuals. However, certain clinical studies showed association of elevated estrogen levels and chronic liver diseases.

Thus, the study affirmed the protective role of estrogens in chronic liver diseases which was also substantiated by studies conducted on ovariectomized experimental models. On the other hand, a few clinical studies also showed the significance of increased estrogen levels in the pathogenesis of chronic liver diseases. Hence, more studies are required at molecular level to investigate the role of estrogen in several forms of chronic liver diseases.


Source: Ezhilarasan D. Critical role of estrogen in the progression of chronic liver diseases. Hepatobiliary Pancreat Dis Int. 2020 Oct;19(5):429-434. 


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