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Concomitant glucocorticoids and PPI use increases fracture risk in RA patients

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eMediNexus    25 February 2021

Rheumatoid arthritis (RA) patients treated with oral glucocorticoids and proton pump inhibitors (PPIs) had an elevated risk for osteoporotic fracture, reported a large cohort study published online in Annals of the Rheumatic Diseases.

Concomitant use of glucocorticoids and PPIs was found to be linked with a 1.6 times increased risk of osteoporotic fracture (adjusted HR 1.60, 95% CI 1.35-1.89), reported researchers. Use of either oral glucocorticoids or PPIs alone was associated with only a 1.2 times increased risk. 

For glucocorticoid alone, the adjusted hazard ratio was 1.23 (95% CI 1.03-1.47), and that for PPI use alone was 1.22 (95% CI 1.05-1.42). This was statistically lower than that for concomitant use of the two drugs… (Medpage Today)

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