Relationship of femoral artery ultrasound measures of atherosclerosis with chronic kidney disease.


eMediNexus    02 January 2018

The purpose of a new study published in the Journal of Vascular Surgery was to investigate whether the presence of atherosclerotic plaque and femoral intima-media thickness (IMT) are associated with kidney function. This was a cross-sectional observational study including 1029 community-living adults. The findings revealed that the mean age of participants was 70 ± 10 years and the mean estimated glomerular filtration rate (eGFR) was 78 ±17 mL/min/1.73 m2. Among these, 15% individuals had eGFR <60 mL/min/1.73 m2, and 25% had femoral artery plaque. While, individuals with femoral artery plaque had mean eGFR approximately 3.0 mL/min/1.73 m2 lower than those without plaque. In addition, the presence of plaque was associated with a 1.7-fold higher odds of eGFR <60 mL/min/1.73 m2. Moreover, these associations were similar in people with normal ankle-brachial index. The directions of associations were similar for femoral IMT measures with eGFR and chronic kidney disease (CKD), but were not statistically significant when adjusted for demographic variables and cardiovascular disease risk factors. From the results, it was concluded that femoral artery plaque is significantly associated with CKD prevalence in community-living individuals, even among those with normal ankle-brachial index. It was stated that femoral artery ultrasound may allow evaluation of relationships and risk factors linking peripheral artery disease (PAD) and kidney disease earlier in their course.

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