A new article published in Advances in Wound Care discussed that dermalfibroblasts are the major cell type in the skin, that originate from distinctlocations of the embryo.

The authors informed that different dermal fibroblastsexhibit distinct roles in skin development, homeostasis and wound healing. Thus,these cells are deemed as potential candidates for cell-based therapies inwound healing.

Recent studies reveal that various fibroblast subtypesin the skin dermis play distinct roles in wound healing and contribute todiverse healing outcomes—including non-healing chronic wound or excessive scarformation, such as hypertrophic scars and keloids—with papillary fibroblastshaving anti-scaring and reticular fibroblasts scar-forming properties. However, the identities and functions of dermal fibroblastsubpopulations in many respects remain unknown. Furthermore, heterogeneousdermal fibroblast populations and their functions are poorly characterized.

It was inferred that refining and advancing theunderstanding of dermal fibroblast heterogeneity and their participation inskin homeostasis and wound healing may create potential therapeuticapplications for non-healing chronic wounds or wounds healing with excessivescaring.

Source:Advancesin Wound Care. 2021Feb 19. doi: 10.1089/wound.2020.1287.