PH-directed Therapy in COPD


Prof MN Krishnan, Calicut    04 January 2018

Treatment of COPD with mild/moderate PH with ET1/PDE5 inhibitors is not beneficial and may be harmful. There is evidence that sildenafil in patients with COPD and severe PH with/without right heart failure is beneficial to improve hemodynamics, exercise tolerance and QoL. Further large randomized studies are required to conclusively establish the role of PH-directed therapy in COPD.

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