Liver Update: Modulation of Gut Microbiota: A promising therapeutics in Alcoholic liver disease |
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Liver Update: Modulation of Gut Microbiota: A promising therapeutics in Alcoholic liver disease

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Alcoholic liver disease (ALD) poses a significant health care burden and is caused by excessive alcohol consumption. ALD has a broad spectrum of hepatic injuries including asymptomatic steatosis, alcoholic steatohepatitis (ASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). There is huge variation in susceptibility of alcoholic patients to develop ALD and its progression to more advanced stages is remarkably affected by several factors such as amount and duration of alcohol abuse. Among these factors, the intestinal microbiota and its metabolites have been recently recognized as important in ALD pathophysiology. Alcohol or ethanol abuse triggers qualitative and quantitative alterations in intestinal flora taxonomic composition, mucosal inflammation, and intestinal barrier derangement. Intestinal hypermeability causes the translocation of viable pathogenic bacteria, Gram-negati...
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