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Liver Update: Deleterious effects of Alcohol on Post-Burn Intestinal Barrier, Immune Cells, and Microbiome.
Alcohol or ethanol is one of the most abused substances, and is one of the leading causes of premature death, globally. Owing to its complexity and direct contact with ingested alcohol, the intestine is the primary source of alcohol-associated pathologies. The gut is the largest reservoir of bacteria in the body, and physiologically, maintains a barrier preventing bacteria from translocating out of the intestinal lumen. However, this intestinal barrier gets compromised following alcohol exposure, causing life-threatening systemic complications including sepsis and multiple organ failure. Alcohol is a main confounding factor in pathology related to trauma. Researches from both human and animal studies showed that alcohol disturbs the intestinal barrier and its function, which is precipitated by a “second hit” from traumatic injury. Disruptions in either the intestinal muc...
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