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Although liver is actively involved in feeding for only the last 20 yr in spite of its key place in energy regulation, this theory is still quite controversial. The transmission of information about liver metabolism done to areas in the brain that receive other information significant to feeding such as from gustatory and central glucoreceptors.
Certain behavioral studies that evaluated feeding in which nutrients or antimetabolites have been infused into the liver are unclear. Nevertheless, liver acts in combination with oral factors and the gastrointestinal tract, which is suggestive of its role in feeding. Researchers have suggested that small effects are produced by glucose infusion into the liver or oral intake of glucose on glucose intake by themselves. These two manipulations concomitantly interacts and provide reliable suppression of subsequent glucose intake. However, fructose when given peripherally is not metabolized by the liver in place of brain and can suppress feeding. These interactions are indicative of the fact that the liver is undoubtedly significant in regulating feeding as a measure of a sequence of integrated events initiating in the mouth, integrated by the brain, and terminating with the suitable behaviors.
Source: Novin D, Robinson K, Culbreth LA, Tordoff MG. Is there a role for the liver in the control of food intake? Am J Clin Nutr. 1985 Nov;42(5 Suppl):1050-62.