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Liver Update: Impact of Intestinal Microbiome in Alcoholic- and Non-alcoholic Liver Diseases
There is rising trend in the prevalence of fatty liver diseases worldwide; post treatment of hepatitis C virus infection becomes more widespread, fatty liver diseases are probable to become most prevalent liver disorders. Fatty liver diseases are correlated to alcohol, obesity, and the metabolic syndrome, however, their mechanisms of pathogenesis are not yet fully understood. Development and progression of fatty liver, alcoholic, and non-alcoholic liver disease (ALD) all are affected by the composition of the microbiota. Besides, intestinal microbiota have the potential to affect pre-cirrhotic and cirrhotic stages of liver diseases, which open a window of novel strategies for their diagnosis, treatment, and study. The current review evaluated the differences and similarities in the cirrhotic and pre-cirrhotic stages of non-alcoholic fatty liver disease (NAFLD) and ALD. Variations ar...
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