Polyethylene glycol is a more effective laxative vis-à-vis lactulose in adults with non-organic constipation
Chronic constipation is a common problem. Patients, including physicians, perceive constipation in different ways; hence, prevalence rates vary. Non-organic constipation is constipation with no underlying medical cause. Initial management of constipation comprises of treatment of underlying etiology (if present) along with recommendations for adequate amounts of dietary fiber and fluids and increasing physical activity. The next step in management involves laxatives (osmotic, bulk and stimulant). Polyethylene glycol (PEG) with/without electrolytes and lactulose are the commonly prescribed osmotic laxatives.A systematic review and meta-analysis was conducted to compare the efficacy of PEG versus placebo or active comparators such as lactulose, for the treatment of non-organic constipation in adults. MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Clinical Trials and Google Scholar d...
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