A rare post-infection complication, Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 (PIMS-TS) has shown neurological features (both the central and peripheral) in about half of the affected children.

Recent research studied such patients and reported that 52.2% of children had new-onset neurological symptoms at presentation. With 52.2% had headaches, 30.4% had encephalopathy or delirium, 30.4% had dysarthria or dysphonia, 19.6% had ataxia, dysmetria, or unsteady gait, 17.4% has myopathy or neuropathy, and 13.04% had hallucinations. While 1 patient had a seizure. Some Patients who underwent neuroimaging at baseline demonstrated abnormalities like reversible splenium signal changes. While those who underwent electroencephalographic monitoring at baseline showed mild to severe encephalopathy. 6 weeks and 6 months follow up showed persistence of the neurological abnormalities with little functional impairment.

PIMS-TS patients have heterogeneous neurological clinical and paraclinical features and neurological involvement is secondary to immune-mediated aetiologies. More studies are needed to predict changes over time and any longer-term neurocognitive effects.

Source: https://specialty.mims.com/topic/neuro-features-common-in-children-with-sars-cov-2-related-inflammatory-syndrome?channel=multi-specialty&elq_mid=55618&elq_cid=42720