Issues and Controversies in the Evolution of Oral Rehydration Therapy (ORT) |
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Issues and Controversies in the Evolution of Oral Rehydration Therapy (ORT)

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A new article published in Tropical Medicine and Infectious Disease reported that the initial studies demonstrating the efficacy of oral glucose-electrolytes solutions in reducing or eliminating the need for i.v. therapy for dehydrationcaused by acute watery diarrheas (AWD), were focused on cholera patients. While later research adapted the oral therapy (ORT) methodology for treatment of non-cholera AWDs, including for pediatric patients. These adaptations included the 2:1 regimen – using 2 parts of the original WHO oral rehydration solution (ORS) formulation followed by 1 part additional plain water, and a “low sodium” packet formulation with similar average electrolyte and glucose concentrations, when dissolved in the recommended volume of water. Moreover, the programmatic desire for a single ORS packet formulation has led to controversy over use of the “lo...
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