PPIs and Covid-19: A paradoxical association
Dr Surya Kant Professor and Head Department of Respiratory Medicine, KGMU ,UP, Lucknow; National Vice Chairman IMA-AMS., 08 June 2021
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The use of proton pump inhibitors (PPIs) has been linked to increased risk of Covid-19 infection and related mortality. The evidence on this however has not been consistent. Adding to the evidence, a new meta-analysis has found that PPIs do not significantly increase risk for COVID-19 infection or death. But it does appear to increase the risk for severe disease and secondary infections. This meta-analysis of 14 articles - randomized controlled trial or an observational study (including cohort and case-control studies) - with over 268,683 participants was conducted to further investigate this association.The association between PPIs and risk of COVID-19 infection was non-significant (OR 1.64, 95% CI 0.54-5.00, P=0.390), as was the risk for COVID-19 mortality (OR 1.91, 95% CI 0.86-4.24, P=0.11).The association between PPIs and risk for progression to severe disease was...
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