Promelanogenic Effects of an Annurca Apple-Based Natural Formulation in Human Melanocytes
A multifaceted combination of both, intrinsic and extrinsic factors, modulates the expression and activity of proteins involved in pigmentation. These factors include – the endocrine and paracrine dynamics, exogenous stimuli such as sunlight and xenobiotics, as well as the rate-limiting enzyme tyrosinase. While several melanogenesis inhibitors are available, the number of melanin activators and tyrosinase stimulators are in limited use.A new study published in Clinical Cosmetic and Investigational Dermatology aimed to explore the biological effects of an Annurca Apple-based nutraceutical preparation (AMS) on melanin production.This study entailed experiments in cellular models of human skin. Both, primary cultures and co-cultures of epidermal melanocytes (HEMa) and follicular keratinocytes (HHFK) were used.The findings revealed that AMS induces in total biocompatibility, a signific...
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