The goal of a recent study published in the American Journal of Medical Genetics was to expand existing knowledge on feeding and gastrointestinal issues among individuals with CHARGE syndrome. This study recruited parents of children and adolescents, in the age-group of 1-18 years, with CHARGE syndrome, with or without feeding/gastrointestinal issues. Parents completed three questionnaires: CHARGE diagnostic characteristics; a Pediatric Assessment Scale for Severe Feeding Problems and a Gastrointestinal Symptoms Scale; along with open-ended questions; 69 completed questionnaires were analyzed. The findings revealed that individuals who were completely tube fed had significantly more feeding difficulties than individuals who were either partially or completely orally fed. Additionally, tube fed individuals experienced more problematic gastrointestinal symptoms. Meanwhile, constipation, vomiting, and choking were reported as the greatest challenges. From the results, it was inferred that problems exist throughout the gastrointestinal tract in many individuals with CHARGE syndrome. However, these issues are more common in individuals who receive nutrition completely through a feeding tube, than in those with at least partial oral feeding behaviors.