Clinical Manifestations and Therapeutic Findings of the Children with Glucose-6-Phosphate Dehydrogenase Deficiency Presenting Favism |
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Clinical Manifestations and Therapeutic Findings of the Children with Glucose-6-Phosphate Dehydrogenase Deficiency Presenting Favism

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Favism, characterized as acute anaemia, because of Glucose-6-phosphate dehydrogenase (G6PD) deficiency is especially caused because of consumption of fava beans. The illness is associated with paleness, jaundice, and hemoglobinuria. A report describes the signs, symptoms and therapeutic findings of the patients with hemolysis due to G6PD deficiency, who was investigated in Shahid Madani Hospital of Khorramabad, Lorestan.

It was a single-centre cross-sectional descriptive study that was conducted on all children with G6PD deficiency-induced hemolysis.

The investigation included a total of 308 children, 64.3% of which were male and 35.7% were female. 

They found-

Jaundice to be the foremost common complaint (82.5%).

Intake of fava bean to be the most common explanation for hemolysis (85.7%). 

Hydration/fluid therapy was rendered to 68% of the kids.

36% of the cases received a blood transfusion

The mean of blood administered was 18.9 cc/kg.

From this study, it had been concluded that hydration therapy is that the most performed treatment within the children presenting favism. It also highlighted that the inaccurate calculation of the quantity of blood needed for transfusion has increased the frequency of blood transfusions and prolonged hospitalization time in these children.

Source: Endocr Metab Immune Disord Drug Targets. 2020 Aug 18. doi: 10.2174/1871530320999200818182905. Epub ahead of print. PMID: 32811422.

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