More diverse gut bacteria and higher abundance of 12 butyrate-producing bacteria have been found to be tied to less insulin resistance and less type 2 diabetes in a population-based observational study.

The study published in JAMA Network Open also identified several bacteria that ferment dietary fiber in the gut to produce butyrate, which may contribute to the protection against type 2 diabetes. The study confirmed that low diversity in gut microbiome is linked with a heightened risk of obesity and type 2 diabetes. A higher abundance of each of seven types of butyrate-producing bacteria, namely Christensenellaceae, Christensenellaceae R7 group, Marvinbryantia, Ruminococcaceae UCG005, Ruminococcaceae UCG008, Ruminococcaceae UCG010, and Ruminococcaceae NK4A214 group, was shown to be tied to lower insulin resistance, after adjusting for confounders like diet and drugs. Additionally, a higher abundance of each of five types of butyrate-producing bacteria, including Clostridiaceae 1, Peptostreptococcaceae, C sensu stricto 1, Intestinibacter, and Romboutsia, was linked with less type 2 diabetes… (Medscape)