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Role of Complement in Recurrence of Glomerulonephritis

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Dr Darshan Rangaswamy, Manipal    11 January 2018

Concurrent monoclonal paraproteinemia, persistent low complements: associated with early recurrence and increased graft loss. Soluble complement protein synthesized by the liver (i.e., Factor H, I, C3) have a high risk of recurrence similar to gain of function mutations in Factor B; living donor transplantation, even in the eculizumab era is not indicated in them. Extensive pre-transplant work-up for the components of the complement system and post-transplant protocol biopsy improves outcomes.

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